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» Challenges of sequencing human genomes
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TCBB
2008
95views more  TCBB 2008»
13 years 8 months ago
Solving the Problem of Trans-Genomic Query with Alignment Tables
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...
BMCBI
2010
135views more  BMCBI 2010»
13 years 9 months ago
GIGA: a simple, efficient algorithm for gene tree inference in the genomic age
Background: Phylogenetic relationships between genes are not only of theoretical interest: they enable us to learn about human genes through the experimental work on their relativ...
Paul D. Thomas
BMCBI
2007
183views more  BMCBI 2007»
13 years 9 months ago
Considerations in the identification of functional RNA structural elements in genomic alignments
Background: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and s...
Tomas Babak, Benjamin J. Blencowe, Timothy R. Hugh...
BMCBI
2006
122views more  BMCBI 2006»
13 years 9 months ago
Genome comparison using Gene Ontology (GO) with statistical testing
Background: Automated comparison of complete sets of genes encoded in two genomes can provide insight on the genetic basis of differences in biological traits between species. Gen...
Zhaotao Cai, Xizeng Mao, Songgang Li, Liping Wei
NAR
2008
159views more  NAR 2008»
13 years 8 months ago
The UCSC Genome Browser Database: 2008 update
The University of California, Santa Cruz, Genome Browser Database (GBD) provides integrated sequence and annotation data for a large collection of vertebrate and model organism ge...
Donna Karolchik, Robert M. Kuhn, Robert Baertsch, ...