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» Challenges of sequencing human genomes
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BMCBI
2004
117views more  BMCBI 2004»
13 years 8 months ago
CisOrtho: A program pipeline for genome-wide identification of transcription factor target genes using phylogenetic footprinting
Background: All known genomes code for a large number of transcription factors. It is important to develop methods that will reveal how these transcription factors act on a genome...
Henry R. Bigelow, Adam S. Wenick, Allan Wong, Oliv...
ALMOB
2008
95views more  ALMOB 2008»
13 years 9 months ago
A stitch in time: Efficient computation of genomic DNA melting bubbles
Background: It is of biological interest to make genome-wide predictions of the locations of DNA melting bubbles using statistical mechanics models. Computationally, this poses th...
Eivind Tøstesen
BMCBI
2006
103views more  BMCBI 2006»
13 years 9 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2004
102views more  BMCBI 2004»
13 years 8 months ago
FRAGS: estimation of coding sequence substitution rates from fragmentary data
Background: Rates of substitution in protein-coding sequences can provide important insights into evolutionary processes that are of biomedical and theoretical interest. Increased...
Estienne C. Swart, Winston A. Hide, Cathal Seoighe
BMCBI
2007
96views more  BMCBI 2007»
13 years 9 months ago
Features generated for computational splice-site prediction correspond to functional elements
Background: Accurate selection of splice sites during the splicing of precursors to messenger RNA requires both relatively well-characterized signals at the splice sites and auxil...
Rezarta Islamaj Dogan, Lise Getoor, W. John Wilbur...