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» Challenges of sequencing human genomes
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BMCBI
2007
135views more  BMCBI 2007»
13 years 7 months ago
Automatic extraction of reliable regions from multiple sequence alignments
Background: High quality multiple alignments are crucial in the transfer of annotation from one genome to another. Multiple alignment methods strive to achieve ever increasing lev...
Timo Lassmann, Erik L. L. Sonnhammer
ICDE
2005
IEEE
157views Database» more  ICDE 2005»
14 years 9 months ago
MoDB: Database System for Synthesizing Human Motion
Enacting and capturing real motion for all potential scenarios is terribly expensive; hence, there is a great demand to synthetically generate realistic human motion. However, it ...
Timothy Edmunds, S. Muthukrishnan, Subarna Sadhukh...
BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
ISMB
2007
13 years 10 months ago
A Chado case study: an ontology-based modular schema for representing genome-associated biological information
Motivation: A few years ago, FlyBase undertook to design a new database schema to store Drosophila data. It would fully integrate genomic sequence and annotation data with bibliog...
Chris Mungall, David B. Emmert
BMCBI
2008
109views more  BMCBI 2008»
13 years 7 months ago
LTRharvest, an efficient and flexible software for de novo detection of LTR retrotransposons
Background: Transposable elements are abundant in eukaryotic genomes and it is believed that they have a significant impact on the evolution of gene and chromosome structure. Whil...
David Ellinghaus, Stefan Kurtz, Ute Willhoeft