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» Challenges of sequencing human genomes
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BMCBI
2010
101views more  BMCBI 2010»
13 years 9 months ago
Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...
Zhengdong D. Zhang, Mark B. Gerstein
CIKM
1994
Springer
14 years 27 days ago
Facilitating Transformations in a Human Genome Project Database
Human Genome Project databases present a confluence of interesting database challenges: rapid schema and data evolution, complex data entry and constraint management, and the need...
Susan B. Davidson, Anthony Kosky, Barbara A. Eckma...
RECOMB
2009
Springer
14 years 9 months ago
Spatial Clustering of Multivariate Genomic and Epigenomic Information
The combination of fully sequence genomes and new technologies for high density arrays and ultra-rapid sequencing enables the mapping of generegulatory and epigenetics marks on a g...
Rami Jaschek, Amos Tanay
BIOCOMP
2006
13 years 10 months ago
Fast Dictionary Lookup in Genomic Information Retrieval
Indexing and retrieval techniques for homology searching of genomic databases are increasingly important as the search tools are facing great challenges of rapid growth in sequence...
Simon M. C. Yuen, Fu-Lai Chung, Robert Wing Pong L...
EDBT
2010
ACM
117views Database» more  EDBT 2010»
14 years 3 months ago
Anchoring millions of distinct reads on the human genome within seconds
With the advent of next-generation DNA sequencing machines, there is an increasing need for the development of computational tools that can anchor accurately and expediently the m...
Tien Huynh, Michail Vlachos, Isidore Rigoutsos