524 search results - page 9 / 105 » Challenges of sequencing human genomes |
ALMOB
2006
13 years 9 months ago
2006
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
TCBB
2010
13 years 3 months ago
2010
This paper integrates the signal, context and structure features for genome-wide promoter recognition, which is critical in many DNA sequence analysis tasks. First, CpG islands ar...
NAR
2011
12 years 11 months ago
2011
Gene duplications are scattered widely throughout the human genome. A single-base difference located in nearly identical duplicated segments may be misjudged as a single nucleotid...
EVOW
2003
Springer
14 years 2 months ago
2003
Springer
Chromosomal aberrations are differences in DNA sequence copy number of chromosome regions 3 . These differences may be crucial genetic events in the development and progression o...
BMCBI
2005
13 years 8 months ago
2005
Background: The availability of the human genome sequence as well as the large number of physically accessible oligonucleotides, cDNA, and BAC clones across the entire genome has ...