The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. For...
- Establishing structure-function relationships on the proteomic scale is a unique challenge faced by bioinformatics and molecular biosciences. Large protein families represent nat...
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...
Background: G-protein-coupled receptors (GPCRs) play a key role in diverse physiological processes and are the targets of almost two-thirds of the marketed drugs. The 3 D structur...
Background: When proteins are subjected to proteolytic digestion and analyzed by mass spectrometry using a method such as 2D LC MS/MS, only a portion of the proteotypic peptides a...
William S. Sanders, Susan M. Bridges, Fiona M. McC...