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BMCBI
2008
125views more  BMCBI 2008»
13 years 8 months ago
XplorSeq: A software environment for integrated management and phylogenetic analysis of metagenomic sequence data
Background: Advances in automated DNA sequencing technology have accelerated the generation of metagenomic DNA sequences, especially environmental ribosomal RNA gene (rDNA) sequen...
Daniel N. Frank
BMCBI
2008
148views more  BMCBI 2008»
13 years 8 months ago
StAR: a simple tool for the statistical comparison of ROC curves
Background: As in many different areas of science and technology, most important problems in bioinformatics rely on the proper development and assessment of binary classifiers. A ...
Ismael A. Vergara, Tomás Norambuena, Evandr...
BMCBI
2007
265views more  BMCBI 2007»
13 years 8 months ago
Large scale clustering of protein sequences with FORCE -A layout based heuristic for weighted cluster editing
Background: Detecting groups of functionally related proteins from their amino acid sequence alone has been a long-standing challenge in computational genome research. Several clu...
Tobias Wittkop, Jan Baumbach, Francisco P. Lobo, S...
BMCBI
2008
127views more  BMCBI 2008»
13 years 8 months ago
MetaMine - A tool to detect and analyse gene patterns in their environmental context
Background: Modern sequencing technologies allow rapid sequencing and bioinformatic analysis of genomes and metagenomes. With every new sequencing project a vast number of new pro...
Uta Bohnebeck, Thierry Lombardot, Renzo Kottmann, ...
BMCBI
2008
159views more  BMCBI 2008»
13 years 8 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin