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» Coding Exon Detection Using Comparative Sequences
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BMCBI
2004
140views more  BMCBI 2004»
13 years 9 months ago
What can we learn from noncoding regions of similarity between genomes?
Background: In addition to known protein-coding genes, large amounts of apparently non-coding sequence are conserved between the human and mouse genomes. It seems reasonable to as...
Thomas A. Down, Tim J. P. Hubbard
BMCBI
2007
183views more  BMCBI 2007»
13 years 10 months ago
Considerations in the identification of functional RNA structural elements in genomic alignments
Background: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and s...
Tomas Babak, Benjamin J. Blencowe, Timothy R. Hugh...
BIBM
2010
IEEE
161views Bioinformatics» more  BIBM 2010»
13 years 7 months ago
Cis-regulatory module detection using constraint programming
We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same t...
Tias Guns, Hong Sun, Kathleen Marchal, Siegfried N...
IMSCCS
2006
IEEE
14 years 3 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
ACMSE
2006
ACM
13 years 11 months ago
Phoenix-based clone detection using suffix trees
A code clone represents a sequence of statements that are duplicated in multiple locations of a program. Clones often arise in source code as a result of multiple cut/paste operat...
Robert Tairas, Jeff Gray