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BMCBI
2008
90views more  BMCBI 2008»
13 years 6 months ago
Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
BMCBI
2010
124views more  BMCBI 2010»
13 years 6 months ago
A factor model to analyze heterogeneity in gene expression
Background: Microarray technology allows the simultaneous analysis of thousands of genes within a single experiment. Significance analyses of transcriptomic data ignore the gene d...
Yuna Blum, Guillaume Le Mignon, Sandrine Lagarrigu...
BMCBI
2010
87views more  BMCBI 2010»
13 years 6 months ago
Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model
Background: Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. Recent studies have shown significant epigenetic pattern...
Jessica L. Larson, Guo-Cheng Yuan
BMCBI
2007
197views more  BMCBI 2007»
13 years 6 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park
BMCBI
2007
102views more  BMCBI 2007»
13 years 6 months ago
Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...