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BMCBI
2006
110views more  BMCBI 2006»
13 years 7 months ago
Design of a combinatorial DNA microarray for protein-DNA interaction studies
Background: Discovery of precise specificity of transcription factors is an important step on the way to understanding the complex mechanisms of gene regulation in eukaryotes. Rec...
Julian Mintseris, Michael B. Eisen
BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...
James H. Bullard, Elizabeth Purdom, Kasper D. Hans...
BMCBI
2008
148views more  BMCBI 2008»
13 years 7 months ago
Automating dChip: toward reproducible sharing of microarray data analysis
Background: During the past decade, many software packages have been developed for analysis and visualization of various types of microarrays. We have developed and maintained the...
Cheng Li
BMCBI
2007
109views more  BMCBI 2007»
13 years 7 months ago
Discarding duplicate ditags in LongSAGE analysis may introduce significant error
Background: During gene expression analysis by Serial Analysis of Gene Expression (SAGE), duplicate ditags are routinely removed from the data analysis, because they are suspected...
Jeppe Emmersen, Anna M. Heidenblut, Annabeth Laurs...
BMCBI
2007
123views more  BMCBI 2007»
13 years 7 months ago
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
Zailong Wang, Pearlly Yan, Dustin P. Potter, Chari...