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BMCBI
2006
165views more  BMCBI 2006»
15 years 4 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig
BMCBI
2006
203views more  BMCBI 2006»
15 years 4 months ago
Independent component analysis reveals new and biologically significant structures in micro array data
Background: An alternative to standard approaches to uncover biologically meaningful structures in micro array data is to treat the data as a blind source separation (BSS) problem...
Attila Frigyesi, Srinivas Veerla, David Lindgren, ...
BMCBI
2006
169views more  BMCBI 2006»
15 years 4 months ago
Assessing protein similarity with Gene Ontology and its use in subnuclear localization prediction
Background: The accomplishment of the various genome sequencing projects resulted in accumulation of massive amount of gene sequence information. This calls for a large-scale comp...
Zhengdeng Lei, Yang Dai
BMCBI
2007
132views more  BMCBI 2007»
15 years 4 months ago
Dependence of paracentric inversion rate on tract length
Background: We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species. The method al...
Thomas L. York, Richard Durrett, Rasmus Nielsen
BMCBI
2007
148views more  BMCBI 2007»
15 years 4 months ago
WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences
Background: This work addresses the problem of detecting conserved transcription factor binding sites and in general regulatory regions through the analysis of sequences from homo...
Giulio Pavesi, Federico Zambelli, Graziano Pesole