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» Comparisons of Protein Family Dynamics
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BMCBI
2008
84views more  BMCBI 2008»
13 years 8 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
ARVLSI
2001
IEEE
289views VLSI» more  ARVLSI 2001»
14 years 10 days ago
A High-Performance 64-bit Adder Implemented in Output Prediction Logic
Output Prediction Logic (OPL) is a technique that can be applied to conventional CMOS logic families to obtain considerable speedups. When applied to static CMOS, OPL retains the ...
Sheng Sun, Larry McMurchie, Carl Sechen
DEXA
2007
Springer
150views Database» more  DEXA 2007»
14 years 2 months ago
Sequence Alignment as a Database Technology Challenge
Abstract. Sequence alignment is an important task for molecular biologists. Because alignment basically deals with approximate string matching on large biological sequence collecti...
Hans Philippi
BMCBI
2007
143views more  BMCBI 2007»
13 years 8 months ago
RNAspa: a shortest path approach for comparative prediction of the secondary structure of ncRNA molecules
Background: In recent years, RNA molecules that are not translated into proteins (ncRNAs) have drawn a great deal of attention, as they were shown to be involved in many cellular ...
Yair Horesh, Tirza Doniger, Shulamit Michaeli, Ron...
BMCBI
2006
149views more  BMCBI 2006»
13 years 8 months ago
Curation of viral genomes: challenges, applications and the way forward
Background: Whole genome sequence data is a step towards generating the 'parts list' of life to understand the underlying principles of Biocomplexity. Genome sequencing ...
Urmila Kulkarni-Kale, Shriram Bhosle, G. Sunitha M...