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» Computational Approaches to Drug Design
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BMCBI
2007
113views more  BMCBI 2007»
13 years 7 months ago
In silico panning for a non-competitive peptide inhibitor
Background: Peptide ligands have tremendous therapeutic potential as efficacious drugs. Currently, more than 40 peptides are available in the market for a drug. However, since cos...
Yukiko Yagi, Kotaro Terada, Takahisa Noma, Kazunor...
GECCO
2007
Springer
179views Optimization» more  GECCO 2007»
14 years 1 months ago
Evolutionary selection of minimum number of features for classification of gene expression data using genetic algorithms
Selecting the most relevant factors from genetic profiles that can optimally characterize cellular states is of crucial importance in identifying complex disease genes and biomark...
Alper Küçükural, Reyyan Yeniterzi...
RECOMB
2008
Springer
14 years 8 months ago
Constructing Treatment Portfolios Using Affinity Propagation
A key problem of interest to biologists and medical researchers is the selection of a subset of queries or treatments that provide maximum utility for a population of targets. For ...
Delbert Dueck, Brendan J. Frey, Nebojsa Jojic, Vla...
AIME
2003
Springer
14 years 27 days ago
Constraint Reasoning in Deep Biomedical Models
Objective: Deep biomedical models are often expressed by means of differential equations. Despite their expressive power, they are difficult to reason about and make decisions, g...
Jorge Cruz, Pedro Barahona
FCCM
2009
IEEE
121views VLSI» more  FCCM 2009»
14 years 2 months ago
FPGA-based Monte Carlo Computation of Light Absorption for Photodynamic Cancer Therapy
—Photodynamic therapy (PDT) is a method of treating cancer that combines light and light-sensitive drugs to selectively destroy cancerous tumours without harming the healthy tiss...
Jason Luu, Keith Redmond, William Lo, Paul Chow, L...