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APBC
2003
120views Bioinformatics» more  APBC 2003»
13 years 11 months ago
From Informatics to Bioinformatics
Informatics has helped in launching molecular biology into the genomic era. It appears certain that informatics will continue to be a major factor in the success of molecular biol...
Vladimir B. Bajic, Vladimir Brusic, Jinyan Li, See...
BMCBI
2004
151views more  BMCBI 2004»
13 years 9 months ago
A computational approach for ordering signal transduction pathway components from genomics and proteomics Data
Background: Signal transduction is one of the most important biological processes by which cells convert an external signal into a response. Novel computational approaches to mapp...
Yin Liu, Hongyu Zhao
GECCO
2007
Springer
131views Optimization» more  GECCO 2007»
14 years 4 months ago
Using feedback to regulate gene expression in a developmental control architecture
We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developme...
Kester Clegg, Susan Stepney, Tim Clarke
ISMB
1998
13 years 11 months ago
BioSim: A New Qualitative Simulation Environment for Molecular Biology
Traditionally, biochemical systems are modelled usingkinetics anddifferential equationsin a quantitative simulator. However,for manybiological processes detailed quantitative info...
Karsten R. Heidtke, Steffen Schulze-Kremer
BMCBI
2008
89views more  BMCBI 2008»
13 years 10 months ago
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
Background: Simulating the major molecular events inside an Escherichia coli cell can lead to a very large number of reactions that compose its overall behaviour. Not only should ...
Marco A. J. Iafolla, Guang Qiang Dong, David R. Mc...