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BMCBI
2004
146views more  BMCBI 2004»
13 years 8 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
BMCBI
2006
138views more  BMCBI 2006»
13 years 8 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
EVOW
2006
Springer
14 years 11 days ago
Hierarchical Clustering, Languages and Cancer
In this paper, we introduce a novel objective function for the hierarchical clustering of data from distance matrices, a very relevant task in Bioinformatics. To test the robustnes...
Pritha Mahata, Wagner Costa, Carlos Cotta, Pablo M...
BMCBI
2007
148views more  BMCBI 2007»
13 years 8 months ago
Evaluation of gene-expression clustering via mutual information distance measure
Background: The definition of a distance measure plays a key role in the evaluation of different clustering solutions of gene expression profiles. In this empirical study we compa...
Ido Priness, Oded Maimon, Irad E. Ben-Gal
ICMLA
2010
13 years 6 months ago
Smoothing Gene Expression Using Biological Networks
Gene expression (microarray) data have been used widely in bioinformatics. The expression data of a large number of genes from small numbers of subjects are used to identify inform...
Yue Fan, Mark A. Kon, Shinuk Kim, Charles DeLisi