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» Contextual alignment of biological sequences
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NIPS
2004
13 years 9 months ago
Discrete profile alignment via constrained information bottleneck
Amino acid profiles, which capture position-specific mutation probabilities, are a richer encoding of biological sequences than the individual sequences themselves. However, profi...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...
TCBB
2010
137views more  TCBB 2010»
13 years 6 months ago
Alignments of RNA Structures
— We describe a theoretical unifying framework to express comparison of RNA structures, which we call alignment hierarchy. This framework relies on the definition of common supe...
Guillaume Blin, Alain Denise, Serge Dulucq, Claire...
BMCBI
2006
156views more  BMCBI 2006»
13 years 7 months ago
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...
RECOMB
2009
Springer
14 years 8 months ago
Lifting Prediction to Alignment of RNA Pseudoknots
Prediction and alignment of RNA pseudoknot structures are NP-hard. Nevertheless, several efficient prediction algorithms by dynamic programming have been proposed for restricted cl...
Mathias Möhl, Rolf Backofen, Sebastian Will
HPDC
2010
IEEE
13 years 8 months ago
Modeling sequence and function similarity between proteins for protein functional annotation
A common task in biological research is to predict function for proteins by comparing sequences between proteins of known and unknown function. This is often done using pair-wise ...
Roger Higdon, Brenton Louie, Eugene Kolker