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» Contextual alignment of biological sequences
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BMCBI
2007
148views more  BMCBI 2007»
13 years 7 months ago
Blast sampling for structural and functional analyses
Background: The post-genomic era is characterised by a torrent of biological information flooding the public databases. As a direct consequence, similarity searches starting with ...
Anne Friedrich, Raymond Ripp, Nicolas Garnier, Emm...
BMCBI
2008
164views more  BMCBI 2008»
13 years 7 months ago
Word correlation matrices for protein sequence analysis and remote homology detection
Background: Classification of protein sequences is a central problem in computational biology. Currently, among computational methods discriminative kernel-based approaches provid...
Thomas Lingner, Peter Meinicke
BMCBI
2011
13 years 2 months ago
PICS-Ord: Unlimited Coding of Ambiguous Regions by Pairwise Identity and Cost Scores Ordination
Background: We present a novel method to encode ambiguously aligned regions in fixed multiple sequence alignments by ‘Pairwise Identity and Cost Scores Ordination’ (PICS-Ord)....
Robert K. Luecking, Brendan P. Hodkinson, Alexandr...
BMCBI
2004
208views more  BMCBI 2004»
13 years 7 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
ISMB
1993
13 years 9 months ago
Detection of Correlations in tRNA Sequences with Structural Implications
Using a flexible representation of biological sequences, we have performed a comparative analysis of 1208 known tRNA sequences. We believe we our technique is a more sensitive met...
Tod M. Klingler, Douglas L. Brutlag