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» Convergent algorithms for protein structural alignment
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BMCBI
2008
145views more  BMCBI 2008»
13 years 7 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
JMLR
2006
115views more  JMLR 2006»
13 years 7 months ago
Structured Prediction, Dual Extragradient and Bregman Projections
We present a simple and scalable algorithm for maximum-margin estimation of structured output models, including an important class of Markov networks and combinatorial models. We ...
Benjamin Taskar, Simon Lacoste-Julien, Michael I. ...
ALMOB
2007
151views more  ALMOB 2007»
13 years 7 months ago
Local sequence alignments statistics: deviations from Gumbel statistics in the rare-event tail
Background: The optimal score for ungapped local alignments of infinitely long random sequences is known to follow a Gumbel extreme value distribution. Less is known about the imp...
Stefan Wolfsheimer, Bernd Burghardt, Alexander K. ...
BMCBI
2007
102views more  BMCBI 2007»
13 years 7 months ago
A comprehensive system for evaluation of remote sequence similarity detection
Background: Accurate and sensitive performance evaluation is crucial for both effective development of better structure prediction methods based on sequence similarity, and for th...
Yuan Qi, Ruslan Sadreyev, Yong Wang, Bong-Hyun Kim...
BMCBI
2006
107views more  BMCBI 2006»
13 years 7 months ago
A reinforced merging methodology for mapping unique peptide motifs in members of protein families
Background: Members of a protein family often have highly conserved sequences; most of these sequences carry identical biological functions and possess similar three-dimensional (...
Hao-Teng Chang, Tun-Wen Pai, Tan-Chi Fan, Bo-Han S...