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» Current approaches to gene regulatory network modelling
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BMCBI
2007
146views more  BMCBI 2007»
13 years 6 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
CONCUR
2005
Springer
14 years 8 days ago
A Compositional Approach to the Stochastic Dynamics of Gene Networks
We propose a compositional approach to the dynamics of gene regulatory networks based on the stochastic π-calculus, and develop a representation of gene network elements which can...
Luca Cardelli
BMCBI
2006
123views more  BMCBI 2006»
13 years 6 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2004
146views more  BMCBI 2004»
13 years 6 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
CANDC
2004
ACM
13 years 6 months ago
The difficult interpretation of transcriptome data: the case of the GATC regulatory network
Genomic analyses on part of Escherichia coli's chromosome had suggested the existence of a GATC regulated network. This has recently been confirmed through a transcriptome an...
Alessandra Riva, Marie-Odile Delorme, Tony Chevali...