Abstract-- In eukaryotic cells, genomic DNAs wrap around beadlike molecules, called nucleosomes, so as to pack more compactly in the nucleus of the cell. The nucleosome is made up ...
— DNA sequence basecalling is commonly regarded as a solved problem, despite significant error rates being reflected in inaccuracies in databases and genome annotations. These er...
Microarray technology is a powerful biotechnology tool which allows researchers to simultaneously evaluate the expression of thousands of genes, if not the entire expressed genome...
Background: Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the eff...
Jeffry D. Sander, Deepak Reyon, Morgan L. Maeder, ...
The stichotrichous ciliates are uni-cellular organisms which undergo a series of complex unscrambling of genetic encodings. This ability to rearrange DNA to produce the correct pr...