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ALMOB
2008
95views more  ALMOB 2008»
13 years 7 months ago
A stitch in time: Efficient computation of genomic DNA melting bubbles
Background: It is of biological interest to make genome-wide predictions of the locations of DNA melting bubbles using statistical mechanics models. Computationally, this poses th...
Eivind Tøstesen
BMCBI
2004
130views more  BMCBI 2004»
13 years 7 months ago
PATTERNFINDER: combined analysis of DNA regulatory sequences and double-helix stability
Background: Regulatory regions that function in DNA replication and gene transcription contain specific sequences that bind proteins as well as less-specific sequences in which th...
Yanlin Huang, David Kowalski
BMCBI
2007
129views more  BMCBI 2007»
13 years 7 months ago
Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping
Background: The Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping. It is known t...
Michael C. Wendl
JCB
1998
129views more  JCB 1998»
13 years 7 months ago
A Sticker-Based Model for DNA Computation
We introduce a new model of molecular computation that we call the sticker model. Like many previous proposals it makes use of DNA strands as the physical substrate in which infor...
Sam T. Roweis, Erik Winfree, Richard Burgoyne, Nic...
BMCBI
2010
167views more  BMCBI 2010»
13 years 7 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...