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RECOMB
2008
Springer
14 years 8 months ago
Duplication Mechanism and Disruptions in Flanking Regions Influence the Fate of Mammalian Gene Duplicates
Here we identify duplicated genes in five mammalian genomes and classify these duplicates based on the mechanisms by which they were generated. Retrotransposition accounts for at l...
Paul Ryvkin, Jin Jun, Edward Hemphill, Craig Nelso...
BMEI
2008
IEEE
14 years 2 months ago
A New Approach for Tree Alignment Based on Local Re-Optimization
Multiple sequence alignment is the most fundamental task in bioinformatics and computational biology. In this paper, we present a new algorithm to conduct multiple sequences align...
Feng Yue, Jijun Tang
DAC
2006
ACM
14 years 1 months ago
Automated design of pin-constrained digital microfluidic arrays for lab-on-a-chip applications*
Microfluidics-based biochips, also referred to as lab-on-a-chip (LoC), are devices that integrate fluid-handling functions such as sample preparation, analysis, separation, and de...
William L. Hwang, Fei Su, Krishnendu Chakrabarty
ICCS
2005
Springer
14 years 1 months ago
SWAT: A New Spliced Alignment Tool Tailored for Handling More Sequencing Errors
Abstract. There are several computer programs that align mRNA with its genomic counterpart to determine exon boundaries. Though most of these programs perform such alignment effici...
Yifeng Li, Hesham H. Ali
IFIP
2004
Springer
14 years 1 months ago
Imperfectness of Data for STS-Based Physical Mapping
In the STS-based mapping, we are requested to obtain the correct order of probes in a DNA sequence from a given set of fragments or equivalently a hybridization matrix A. It is wel...
Hiro Ito, Kazuo Iwama, Takeyuki Tamura