The challenge of similarity search in massive DNA sequence databases has inspired major changes in BLAST-style alignment tools, which accelerate search by inspecting only pairs of...
PSI-BLAST remains one of the popular tools for searching remote homologs in sequence databases. We recently demonstrated that hybrid alignment can function as the alignment core f...
- Metagenomics is the study of environmental samples. Because few tools exist for metagenomic analysis, a natural step has been to utilize the popular homology tool, BLAST, to sear...
Background: During the last few years, DNA sequence analysis has become one of the primary means of taxonomic identification of species, particularly so for species that are minut...
R. Henrik Nilsson, Erik Kristiansson, Martin Ryber...
Background: Until today, analysis of 16S ribosomal RNA (rRNA) sequences has been the de-facto gold standard for the assessment of phylogenetic relationships among prokaryotes. How...