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CPHYSICS
2007
84views more  CPHYSICS 2007»
13 years 7 months ago
Structural models of human big conductance calcium- and voltage-gated potassium channels
Human big conductance Ca2+ - and voltage-gated K+ channels (hBK) are putative drug targets for cardiovascular, respiratory and urological diseases. Here we have used molecular sim...
Agata Kranjc, Claudio Anselmi, Paolo Carloni, Fran...
JWSR
2007
99views more  JWSR 2007»
13 years 7 months ago
A Metamorphic Testing Approach for Online Testing of Service-Oriented Software Applications
: Testing the correctness of services assures the functional quality of service-oriented application. A service-oriented application may bind dynamically to its supportive services...
W. Chan, S. Cheung, K. Leung
ECCB
2002
IEEE
14 years 21 days ago
Stochastic roadmap simulation for the study of ligand-protein interactions
The dynamics of ligand-protein interactions are necessary to understand for the design of novel therapeutic agents. In this paper, we establish the use of Stochastic Roadmap Simul...
Mehmet Serkan Apaydin, Carlos Guestrin, Chris Varm...
BMCBI
2010
106views more  BMCBI 2010»
13 years 7 months ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron
BMCBI
2010
114views more  BMCBI 2010»
13 years 7 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...