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BMCBI
2008
99views more  BMCBI 2008»
13 years 11 months ago
Exhaustive prediction of disease susceptibility to coding base changes in the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Ba...
Vinayak Kulkarni, Mounir Errami, Robert Barber, Ha...
BMCBI
2007
110views more  BMCBI 2007»
13 years 11 months ago
Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy
Background: The design of long oligonucleotides for spotted DNA microarrays requires detailed attention to ensure their optimal performance in the hybridization process. The main ...
Guangan Hu, Manuel Llinás, Jingguang Li, Pe...
BIODATAMINING
2008
163views more  BIODATAMINING 2008»
13 years 11 months ago
Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processing
Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in parti...
Saravana K. Kumarasamy, Yunshi Wang, Vignesh Viswa...
GECCO
2007
Springer
177views Optimization» more  GECCO 2007»
14 years 5 months ago
Takeover times on scale-free topologies
The topological properties of a network directly impact the flow of information through a system. In evolving populations, the topology of inter-individual interactions affects th...
Joshua L. Payne, Margaret J. Eppstein
BMCBI
2007
161views more  BMCBI 2007»
13 years 11 months ago
Efficient classification of complete parameter regions based on semidefinite programming
Background: Current approaches to parameter estimation are often inappropriate or inconvenient for the modelling of complex biological systems. For systems described by nonlinear ...
Lars Kuepfer, Uwe Sauer, Pablo A. Parrilo