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BIBM
2008
IEEE
217views Bioinformatics» more  BIBM 2008»
14 years 1 months ago
Combining Hierarchical Inference in Ontologies with Heterogeneous Data Sources Improves Gene Function Prediction
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating thes...
Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon ...
BMCBI
2005
95views more  BMCBI 2005»
13 years 7 months ago
Commensurate distances and similar motifs in genetic congruence and protein interaction networks in yeast
Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growt...
Ping Ye, Brian D. Peyser, Forrest A. Spencer, Joel...
BMCBI
2006
174views more  BMCBI 2006»
13 years 7 months ago
Genome wide prediction of protein function via a generic knowledge discovery approach based on evidence integration
Background: The automation of many common molecular biology techniques has resulted in the accumulation of vast quantities of experimental data. One of the major challenges now fa...
Jianghui Xiong, Simon Rayner, Kunyi Luo, Yinghui L...
KDD
2004
ACM
135views Data Mining» more  KDD 2004»
14 years 7 months ago
Discovering additive structure in black box functions
Many automated learning procedures lack interpretability, operating effectively as a black box: providing a prediction tool but no explanation of the underlying dynamics that driv...
Giles Hooker
BMCBI
2010
136views more  BMCBI 2010»
13 years 7 months ago
A hub-attachment based method to detect functional modules from confidence-scored protein interactions and expression profiles
Background: Many research results show that the biological systems are composed of functional modules. Members in the same module usually have common functions. This is useful inf...
Chia-Hao Chin, Shu-Hwa Chen, Chin-Wen Ho, Ming-Tat...