Commensurate distances and similar motifs in genetic congruence and protein interaction networks in yeast

Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growth defect, but the double mutant is lethal or exhibits slow growth, the interaction is termed synthetic lethality or synthetic fitness. These genetic interactions reveal gene redundancy and compensating pathways. Recently available large-scale data sets of genetic interactions and protein interactions in Saccharomyces cerevisiae provide a unique opportunity to elucidate the topological structure of biological pathways and how genes function in these pathways. Results: We have defined congruent genes as pairs of genes with similar sets of genetic interaction partners and constructed a genetic congruence network by linking congruent genes. By comparing path lengths in three types of networks (genetic interaction, genetic congruence, and protein interaction), we discovered that high genetic congruence not only ex...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Ping Ye, Brian D. Peyser, Forrest A. Spencer, Joel S. Bader
• Keywords: BMCBI 2005, Genetic Congruence, Genetic Interaction, Protein Interactions