High-throughput gene-expression studies result in lists of differentially expressed genes. Most current meta-analyses of these gene lists include searching for significant members...
Jignesh R. Parikh, Bertram Klinger, Yu Xia, Jarrod...
Background: The cellular signaling pathway (network) is one of the main topics of organismic investigations. The intracellular interactions between genes in a signaling pathway ar...
Biomarker discovery for complex diseases is a challenging problem. Most of the existing approaches identify individual genes as disease markers, thereby missing the interactions a...
Rohit Gupta, Smita Agrawal, Navneet Rao, Ze Tian, ...
Background: Co-evolution is the process in which two (or more) sets of orthologs exhibit a similar or correlative pattern of evolution. Co-evolution is a powerful way to learn abo...
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...