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» Discriminative Discovery of Transcription Factor Binding Sit...
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BMCBI
2005
169views more  BMCBI 2005»
13 years 7 months ago
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes
Background: Cis-regulatory modules are combinations of regulatory elements occurring in close proximity to each other that control the spatial and temporal expression of genes. Th...
Voichita D. Marinescu, Isaac S. Kohane, Alberto Ri...
BMCBI
2006
87views more  BMCBI 2006»
13 years 7 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
BMCBI
2007
92views more  BMCBI 2007»
13 years 7 months ago
Nanopore current transduction analysis of protein binding to non-terminal and terminal DNA regions: analysis of transcription fa
Background: Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are of this type,...
Stephen Winters-Hilt, Amanda Davis, Iftekhar Amin,...
BMCBI
2006
75views more  BMCBI 2006»
13 years 7 months ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard
ICANN
2007
Springer
14 years 1 months ago
Identifying Binding Sites in Sequential Genomic Data
The identification of cis-regulatory binding sites in DNA is a difficult problem in computational biology. To obtain a full understanding of the complex machinery embodied in genet...
Mark Robinson, Cristina González Castellano...