31 search results - page 6 / 7 » Docking small ligands in flexible binding sites |
BMCBI
2006
13 years 8 months ago
2006
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
BMCBI
2011
13 years 3 days ago
2011
Background: One of the strategies for protein function annotation is to search particular structural motifs that are known to be shared by proteins with a given function. Results:...
BMCBI
2008
13 years 8 months ago
2008
Background: Virtual or in silico ligand screening combined with other computational methods is one of the most promising methods to search for new lead compounds, thereby greatly ...
JCC
2008
13 years 8 months ago
2008
Abstract: We present a method for simultaneous three-dimensional (3D) structure generation and pharmacophorebased alignment using a self-organizing algorithm called Stochastic Prox...
BMCBI
2007
13 years 8 months ago
2007
Background: Correct temporal and spatial gene expression during metazoan development relies on combinatorial interactions between different transcription factors. As a consequence...