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BMCBI
2007
114views more  BMCBI 2007»
13 years 8 months ago
Mining and state-space modeling and verification of sub-networks from large-scale biomolecular networks
Background: Biomolecular networks dynamically respond to stimuli and implement cellular function. Understanding these dynamic changes is the key challenge for cell biologists. As ...
Xiaohua Hu, Fang-Xiang Wu
CDC
2009
IEEE
161views Control Systems» more  CDC 2009»
14 years 1 months ago
Network structure preserving model reduction with weak a priori structural information
— This paper extends a state projection method for structure preserving model reduction to situations where only a weaker notion of system structure is available. This weaker not...
Enoch Yeung, Jorge M. Goncalves, Henrik Sandberg, ...
RECOMB
2008
Springer
14 years 8 months ago
High-Resolution Modeling of Cellular Signaling Networks
A central challenge in systems biology is the reconstruction of biological networks from high-throughput data sets. A particularly difficult case of this is the inference of dynami...
Michael Baym, Chris Bakal, Norbert Perrimon, Bonni...
ISMB
2004
13 years 9 months ago
Predicting gene regulation by sigma factors in Bacillus subtilis from genome-wide data
Motivation: Sigma factors regulate the expression of genes in Bacillus subtilis at the transcriptional level. First we assess the ability of currently available gene regulatory ne...
Michiel J. L. de Hoon, Yuko Makita, Seiya Imoto, K...
BMCBI
2008
116views more  BMCBI 2008»
13 years 8 months ago
Gene Ontology annotations: what they mean and where they come from
To address the challenges of information integration and retrieval, the computational genomics community increasingly has come to rely on the methodology of creating annotations o...
David P. Hill, Barry Smith, Monica S. McAndrews-Hi...