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» Dynamic sensitivity analysis of biological systems
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BMCBI
2005
88views more  BMCBI 2005»
13 years 7 months ago
Using large-scale perturbations in gene network reconstruction
Background: Recent analysis of the yeast gene network shows that most genes have few inputs, indicating that enumerative gene reconstruction methods are both useful and computatio...
Thomas MacCarthy, Andrew Pomiankowski, Robert Seym...
ISCAS
2006
IEEE
162views Hardware» more  ISCAS 2006»
14 years 1 months ago
Silicon neurons that phase-lock
Abstract—We present a silicon neuron with a dynamic, active leak that enables precise spike-timing with respect to a time-varying input signal. Our neuron models the mammalian bu...
J. H. Wittig Jr., Kwabena Boahen
BMCBI
2008
154views more  BMCBI 2008»
13 years 7 months ago
Bayesian models and meta analysis for multiple tissue gene expression data following corticosteroid administration
Background: This paper addresses key biological problems and statistical issues in the analysis of large gene expression data sets that describe systemic temporal response cascade...
Yulan Liang, Arpad Kelemen
JUCS
2010
215views more  JUCS 2010»
13 years 2 months ago
A Multidisciplinary Survey of Computational Techniques for the Modelling, Simulation and Analysis of Biochemical Networks
: All processes of life are controlled by networks of interacting biochemical components. The purpose of modelling these networks is manifold. From a theoretical point of view it a...
James Decraene, Thomas Hinze
BMCBI
2010
104views more  BMCBI 2010»
13 years 7 months ago
Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy
Background: Several diseases, many of which nowadays pandemic, consist of multifactorial pathologies. Paradigmatic examples come from the immune response to pathogens, in which ca...
Anil Sorathiya, Andrea Bracciali, Pietro Liò...