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BMCBI
2010
122views more  BMCBI 2010»
13 years 7 months ago
Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data
Background: Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduc...
Kai-Lin Tang, Tong-Hua Li, Wen-Wei Xiong, Kai Chen
ESWA
2008
140views more  ESWA 2008»
13 years 7 months ago
Web taxonomy integration with hierarchical shrinkage algorithm and fine-grained relations
We address the problem of integrating web taxonomies from different real Internet applications. Integrating web taxonomies is to transfer instances from a source to target taxonom...
Chia-Wei Wu, Richard Tzong-Han Tsai, Cheng-Wei Lee...
BMCBI
2006
159views more  BMCBI 2006»
13 years 7 months ago
Prediction of protein continuum secondary structure with probabilistic models based on NMR solved structures
Background: The structure of proteins may change as a result of the inherent flexibility of some protein regions. We develop and explore probabilistic machine learning methods for...
Mikael Bodén, Zheng Yuan, Timothy L. Bailey
BMCBI
2006
119views more  BMCBI 2006»
13 years 7 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
BMCBI
2007
116views more  BMCBI 2007»
13 years 7 months ago
Clustering protein environments for function prediction: finding PROSITE motifs in 3D
Background: Structural genomics initiatives are producing increasing numbers of threedimensional (3D) structures for which there is little functional information. Structure-based ...
Sungroh Yoon, Jessica C. Ebert, Eui-Young Chung, G...