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BMCBI
2004
142views more  BMCBI 2004»
13 years 8 months ago
GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies
Background: Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed...
Bing Zhang, Denise Schmoyer, Stefan Kirov, Jay Sno...
BMCBI
2011
13 years 2 days ago
To aggregate or not to aggregate high-dimensional classifiers
Background: High-throughput functional genomics technologies generate large amount of data with hundreds or thousands of measurements per sample. The number of sample is usually m...
Cheng-Jian Xu, Huub C. J. Hoefsloot, Age K. Smilde
TIP
2011
162views more  TIP 2011»
13 years 3 months ago
Kernel Maximum Autocorrelation Factor and Minimum Noise Fraction Transformations
—This paper introduces kernel versions of maximum autocorrelation factor (MAF) analysis and minimum noise fraction (MNF) analysis. The kernel versions are based upon a dual formu...
Allan Aasbjerg Nielsen
BMCBI
2010
115views more  BMCBI 2010»
13 years 8 months ago
Importance of replication in analyzing time-series gene expression data: Corticosteroid dynamics and circadian patterns in rat l
Background: Microarray technology is a powerful and widely accepted experimental technique in molecular biology that allows studying genome wide transcriptional responses. However...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
BMCBI
2007
99views more  BMCBI 2007»
13 years 8 months ago
Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Ki
Background: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure ...
Jenny Gu, Philip E. Bourne