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BMCBI
2008
202views more  BMCBI 2008»
13 years 9 months ago
Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data
Background: Integrating data from multiple global assays and curated databases is essential to understand the spatiotemporal interactions within cells. Different experiments measu...
Yuji Zhang, Jianhua Xuan, Benildo de los Reyes, Ro...
BMCBI
2007
167views more  BMCBI 2007»
13 years 9 months ago
Applying negative rule mining to improve genome annotation
Background: Unsupervised annotation of proteins by software pipelines suffers from very high error rates. Spurious functional assignments are usually caused by unwarranted homolog...
Irena I. Artamonova, Goar Frishman, Dmitrij Frishm...
CORR
2010
Springer
177views Education» more  CORR 2010»
13 years 9 months ago
Supervised Random Walks: Predicting and Recommending Links in Social Networks
Predicting the occurrence of links is a fundamental problem in networks. In the link prediction problem we are given a snapshot of a network and would like to infer which interact...
Lars Backstrom, Jure Leskovec
BMCBI
2006
138views more  BMCBI 2006»
13 years 8 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
BMCBI
2006
103views more  BMCBI 2006»
13 years 8 months ago
Domain-based small molecule binding site annotation
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
Kevin A. Snyder, Howard J. Feldman, Michel Dumonti...