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BMCBI
2010
141views more  BMCBI 2010»
13 years 10 months ago
BioPhysConnectoR: Connecting Sequence Information and Biophysical Models
Background: One of the most challenging aspects of biomolecular systems is the understanding of the coevolution in and among the molecule(s). A complete, theoretical picture of th...
Franziska Hoffgaard, Philipp Weil, Kay Hamacher
BMCBI
2010
117views more  BMCBI 2010»
13 years 10 months ago
Using jackknife to assess the quality of gene order phylogenies
Background: In recent years, gene order data has attracted increasing attention from both biologists and computer scientists as a new type of data for phylogenetic analysis. If ge...
Jian Shi, Yiwei Zhang, Haiwei Luo, Jijun Tang
BMCBI
2007
102views more  BMCBI 2007»
13 years 10 months ago
Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties
Background: Homology is a key concept in both evolutionary biology and genomics. Detection of homology is crucial in fields like the functional annotation of protein sequences and...
Jos Boekhorst, Berend Snel
CORR
2010
Springer
117views Education» more  CORR 2010»
13 years 10 months ago
Evolution with Drifting Targets
We consider the question of the stability of evolutionary algorithms to gradual changes, or drift, in the target concept. We define an algorithm to be resistant to drift if, for s...
Varun Kanade, Leslie G. Valiant, Jennifer Wortman ...
BMCBI
2006
85views more  BMCBI 2006»
13 years 10 months ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen