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BMCBI
2010
124views more  BMCBI 2010»
13 years 7 months ago
Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: Transcriptional dynamics and regu
Background: Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both benefici...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
BMCBI
2007
155views more  BMCBI 2007»
13 years 7 months ago
Current approaches to gene regulatory network modelling
Many different approaches have been developed to model and simulate gene regulatory networks. We proposed the following categories for gene regulatory network models: network part...
Thomas Schlitt, Alvis Brazma
BIOINFORMATICS
2006
118views more  BIOINFORMATICS 2006»
13 years 7 months ago
A probabilistic dynamical model for quantitative inference of the regulatory mechanism of transcription
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Magnus Rattray, Neil D. Lawrenc...
JMLR
2012
11 years 10 months ago
Bayesian regularization of non-homogeneous dynamic Bayesian networks by globally coupling interaction parameters
To relax the homogeneity assumption of classical dynamic Bayesian networks (DBNs), various recent studies have combined DBNs with multiple changepoint processes. The underlying as...
Marco Grzegorczyk, Dirk Husmeier
BMCBI
2005
189views more  BMCBI 2005»
13 years 7 months ago
Quantitative inference of dynamic regulatory pathways via microarray data
Background: The cellular signaling pathway (network) is one of the main topics of organismic investigations. The intracellular interactions between genes in a signaling pathway ar...
Wen-Chieh Chang, Chang-Wei Li, Bor-Sen Chen