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BMCBI
2007
134views more  BMCBI 2007»
13 years 7 months ago
Automatic generation of 3D motifs for classification of protein binding sites
Background: Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of prote...
Jean-Christophe Nebel, Pawel Herzyk, David R. Gilb...
BMCBI
2010
179views more  BMCBI 2010»
13 years 7 months ago
A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties
Background: Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited ...
Zhuhong You, Zheng Yin, Kyungsook Han, De-Shuang H...
BMCBI
2010
174views more  BMCBI 2010»
13 years 7 months ago
The effect of prior assumptions over the weights in BayesPI with application to study protein-DNA interactions from ChIP-based h
Background: To further understand the implementation of hyperparameters re-estimation technique in Bayesian hierarchical model, we added two more prior assumptions over the weight...
Junbai Wang
BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
BMCBI
2011
12 years 11 months ago
In-silico prediction of disorder content using hybrid sequence representation
Background: Intrinsically disordered proteins play important roles in various cellular activities and their prevalence was implicated in a number of human diseases. The knowledge ...
Marcin J. Mizianty, Tuo Zhang, Bin Xue, Yaoqi Zhou...