Background: Relating features of protein sequences to structural hinges is important for identifying domain boundaries, understanding structure-function relationships, and designi...
Samuel Flores, Long J. Lu, Julie Yang, Nicholas Ca...
This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...
Background: Since the publication of the first draft of the human genome in 2000, bioinformatic data have been accumulating at an overwhelming pace. Currently, more than 3 million...
Elijah Roberts, John Eargle, Dan Wright, Zaida Lut...
Protein structure comparison is important for elucidation of evolutionary relationships, function and functionally important amino acid residues. We propose Geometric Invariant bas...
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...