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» Exploration of Evolutionary Relations between Protein Struct...
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NAR
2010
106views more  NAR 2010»
13 years 2 months ago
Protein Geometry Database: a flexible engine to explore backbone conformations and their relationships to covalent geometry
The backbone bond lengths, bond angles, and planarity of a protein are influenced by the backbone conformation (u,w), but no tool exists to explore these relationships, leaving th...
Donald S. Berkholz, Peter B. Krenesky, John R. Dav...
BIB
2007
82views more  BIB 2007»
13 years 7 months ago
High-throughput modeling and analysis of protein structural dynamics
Protein function is a dynamic property closely related to the conformational mechanisms of protein structure in its physiological environment. To understand and control the functi...
Xiong Liu, Hassan A. Karimi
BMCBI
2006
100views more  BMCBI 2006»
13 years 7 months ago
STAR: predicting recombination sites from amino acid sequence
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...
Denis C. Bauer, Mikael Bodén, Ricarda Thier...
GECCO
2005
Springer
119views Optimization» more  GECCO 2005»
14 years 1 months ago
A multi-objective evolutionary approach to peptide structure redesign and stabilization
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...
Tim Hohm, Daniel Hoffmann
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Inter-residue distances derived from fold contact propensities correlate with evolutionary substitution costs
Background: The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In p...
Gareth Williams, Patrick Doherty