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BMCBI
2010
144views more  BMCBI 2010»
13 years 8 months ago
Super-sparse principal component analyses for high-throughput genomic data
Background: Principal component analysis (PCA) has gained popularity as a method for the analysis of highdimensional genomic data. However, it is often difficult to interpret the ...
Donghwan Lee, Woojoo Lee, Youngjo Lee, Yudi Pawita...
BMCBI
2008
153views more  BMCBI 2008»
13 years 8 months ago
Estimating the size of the solution space of metabolic networks
Background: Cellular metabolism is one of the most investigated system of biological interactions. While the topological nature of individual reactions and pathways in the network...
Alfredo Braunstein, Roberto Mulet, Andrea Pagnani
BMCBI
2006
179views more  BMCBI 2006»
13 years 8 months ago
Multiscale Hy3S: Hybrid stochastic simulation for supercomputers
Background: Stochastic simulation has become a useful tool to both study natural biological systems and design new synthetic ones. By capturing the intrinsic molecular fluctuation...
Howard Salis, Vassilios Sotiropoulos, Yiannis N. K...
DATAMINE
2006
89views more  DATAMINE 2006»
13 years 8 months ago
Scalable Clustering Algorithms with Balancing Constraints
Clustering methods for data-mining problems must be extremely scalable. In addition, several data mining applications demand that the clusters obtained be balanced, i.e., be of ap...
Arindam Banerjee, Joydeep Ghosh
BMCBI
2007
59views more  BMCBI 2007»
13 years 8 months ago
Environment specific substitution tables for thermophilic proteins
Background: Thermophilic organisms are able to live at high temperatures ranging from 50 to > 100°C. Their proteins must be sufficiently stable to function under these extreme...
K. Mizuguchi, M. Sele, Maria Vittoria Cubellis