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BMCBI
2010
13 years 9 months ago
2010
Background: Next-generation sequencing technologies allow researchers to obtain millions of sequence reads in a single experiment. One important use of the technology is the seque...
BMCBI
2010
13 years 9 months ago
2010
Background: Proteins show a great variety of 3D conformations, which can be used to infer their evolutionary relationship and to classify them into more general groups; therefore ...
BMCBI
2007
13 years 9 months ago
2007
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
BMCBI
2007
13 years 9 months ago
2007
Background: Many algorithms exist for protein structural alignment, based on internal protein coordinates or on explicit superposition of the structures. These methods are usually...
BMCBI
2007
13 years 9 months ago
2007
Background: Identifying syntenic regions, i.e., blocks of genes or other markers with evolutionary conserved order, and quantifying evolutionary relatedness between genomes in ter...