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BMCBI
2010
117views more  BMCBI 2010»
13 years 9 months ago
Automatic, context-specific generation of Gene Ontology slims
Background: The use of ontologies to control vocabulary and structure annotation has added value to genomescale data, and contributed to the capture and re-use of knowledge across...
Melissa J. Davis, Muhammad Shoaib B. Sehgal, Mark ...
BMCBI
2010
144views more  BMCBI 2010»
13 years 9 months ago
Graph-based clustering and characterization of repetitive sequences in next-generation sequencing data
Background: The investigation of plant genome structure and evolution requires comprehensive characterization of repetitive sequences that make up the majority of higher plant nuc...
Petr Novák, Pavel Neumann, Jirí Maca...
BMCBI
2010
105views more  BMCBI 2010»
13 years 9 months ago
Predicting phenotypic traits of prokaryotes from protein domain frequencies
Background: Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predict...
Thomas Lingner, Stefanie Mühlhausen, Toni Gab...
BMCBI
2007
130views more  BMCBI 2007»
13 years 9 months ago
HMM-ModE - Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying e
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
Prashant K. Srivastava, Dhwani K. Desai, Soumyadee...
BMCBI
2010
148views more  BMCBI 2010»
13 years 9 months ago
Structuring heterogeneous biological information using fuzzy clustering of k-partite graphs
Background: Extensive and automated data integration in bioinformatics facilitates the construction of large, complex biological networks. However, the challenge lies in the inter...
Mara L. Hartsperger, Florian Blöchl, Volker S...
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