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RECOMB
2010
Springer
13 years 10 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
BMCBI
2006
151views more  BMCBI 2006»
13 years 8 months ago
Modeling Sage data with a truncated gamma-Poisson model
Background: Serial Analysis of Gene Expressions (SAGE) produces gene expression measurements on a discrete scale, due to the finite number of molecules in the sample. This means t...
Helene H. Thygesen, Aeilko H. Zwinderman
RECOMB
2002
Springer
14 years 8 months ago
Monotony of surprise and large-scale quest for unusual words
The problem of characterizing and detecting recurrent sequence patterns such as substrings or motifs and related associations or rules is variously pursued in order to compress da...
Alberto Apostolico, Mary Ellen Bock, Stefano Lonar...
BMCBI
2008
99views more  BMCBI 2008»
13 years 8 months ago
Multiple organism algorithm for finding ultraconserved elements
Background: Ultraconserved elements are nucleotide or protein sequences with 100% identity (no mismatches, insertions, or deletions) in the same organism or between two or more or...
Scott Christley, Neil F. Lobo, Gregory R. Madey
BMCBI
2007
138views more  BMCBI 2007»
13 years 8 months ago
Fast computation of distance estimators
Background: Some distance methods are among the most commonly used methods for reconstructing phylogenetic trees from sequence data. The input to a distance method is a distance m...
Isaac Elias, Jens Lagergren