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BMCBI
2007
216views more  BMCBI 2007»
13 years 7 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
BMCBI
2007
101views more  BMCBI 2007»
13 years 7 months ago
Robust detection and verification of linear relationships to generate metabolic networks using estimates of technical errors
Background: The size and magnitude of the metabolome, the ratio between individual metabolites and the response of metabolic networks is controlled by multiple cellular factors. A...
Frank Kose, Jan Budczies, Matthias Holschneider, O...
BMCBI
2007
177views more  BMCBI 2007»
13 years 7 months ago
The BioPrompt-box: an ontology-based clustering tool for searching in biological databases
Background: High-throughput molecular biology provides new data at an incredible rate, so that the increase in the size of biological databanks is enormous and very rapid. This sc...
Claudio Corsi, Paolo Ferragina, Roberto Marangoni
BMCBI
2007
99views more  BMCBI 2007»
13 years 7 months ago
Towards validating the hypothesis of phylogenetic profiling
Background: As the number of fully sequenced genome increases, the need is greater for bioinformatics to predict or annotate genes of a newly sequenced genome. Ever since Eisenber...
Raja Loganantharaj, Mazen Atwi
BMCBI
2007
123views more  BMCBI 2007»
13 years 7 months ago
Robust clustering in high dimensional data using statistical depths
Background: Mean-based clustering algorithms such as bisecting k-means generally lack robustness. Although componentwise median is a more robust alternative, it can be a poor cent...
Yuanyuan Ding, Xin Dang, Hanxiang Peng, Dawn Wilki...