Accurately aligning distant protein sequences is notoriously difficult. A recent approach to improving alignment accuracy is to use additional information such as predicted seconda...
Background: Structural similarities among proteins can provide valuable insight into their functional mechanisms and relationships. As the number of available three-dimensional (3...
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
Amy Egan, Anup Mahurkar, Jonathan Crabtree, Jonath...
Background: In the study of adaptive evolution, it is important to detect the protein coding sites where natural selection is acting. In general, the ratio of the rate of non-syno...
Yong Seok Lee, Tae-Hyung Kim, Tae-Wook Kang, Won-H...
In this paper we present a general framework to study sequences of search activities performed by a user. Our framework provides (i) a vocabulary to discuss types of features, mod...
Qiaozhu Mei, Kristina Klinkner, Ravi Kumar, Andrew...