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BMCBI
2007
122views more  BMCBI 2007»
13 years 7 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
GECCO
2005
Springer
149views Optimization» more  GECCO 2005»
14 years 1 months ago
There's more to a model than code: understanding and formalizing in silico modeling experience
Mapping biology into computation has both a domain specific aspect – biological theory – and a methodological aspect – model development. Computational modelers have implici...
Janet Wiles, Nicholas Geard, James Watson, Kai Wil...
WOB
2004
13 years 9 months ago
An Integrated Model for Cellular Analysis
ABSTRACT. We present the MOlecular NETwork (MONET) ontology as a model to integrate data from different networks that govern cell function. To achieve this, different existing onto...
Eduardo Battistella, José Souza, Clá...
CISIM
2008
IEEE
14 years 2 months ago
Evolution Induced Secondary Immunity: An Artificial Immune System Based Intrusion Detection System
The analogy between Immune Systems and Intrusion Detection Systems encourage the use of Artificial Immune Systems for anomaly detection in computer networks. This paper describes ...
Divyata Dal, Siby Abraham, Ajith Abraham, Sugata S...
BMCBI
2010
115views more  BMCBI 2010»
13 years 7 months ago
Multiconstrained gene clustering based on generalized projections
Background: Gene clustering for annotating gene functions is one of the fundamental issues in bioinformatics. The best clustering solution is often regularized by multiple constra...
Jia Zeng, Shanfeng Zhu, Alan Wee-Chung Liew, Hong ...