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» From Sequence to Biology: The Impact on Bioinformatics
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CSB
2002
IEEE
103views Bioinformatics» more  CSB 2002»
14 years 15 days ago
Protein-Based Analysis of Alternative Splicing in the Human Genome
Understanding the functional significance of alternative splicing and other mechanisms that generate RNA transcript diversity is an important challenge facing modern-day molecular...
Ann E. Loraine, Gregg A. Helt, Melissa S. Cline, M...
BMCBI
2010
127views more  BMCBI 2010»
13 years 7 months ago
PeptideMine - A webserver for the design of peptides for protein-peptide binding studies derived from protein-protein interactom
Background: Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target prote...
Khader Shameer, Lalima L. Madan, Shivamurthy Veera...
SDM
2004
SIAM
211views Data Mining» more  SDM 2004»
13 years 9 months ago
Using Support Vector Machines for Classifying Large Sets of Multi-Represented Objects
Databases are a key technology for molecular biology which is a very data intensive discipline. Since molecular biological databases are rather heterogeneous, unification and data...
Hans-Peter Kriegel, Peer Kröger, Alexey Pryak...
BMCBI
2008
178views more  BMCBI 2008»
13 years 7 months ago
A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic ana
Background: Protein remote homology detection and fold recognition are central problems in bioinformatics. Currently, discriminative methods based on support vector machine (SVM) ...
Bin Liu, Xiaolong Wang, Lei Lin, Qiwen Dong, Xuan ...
CSB
2004
IEEE
109views Bioinformatics» more  CSB 2004»
13 years 11 months ago
Rec-I-DCM3: A Fast Algorithmic Technique for Reconstructing Large Phylogenetic Trees
Phylogenetic trees are commonly reconstructed based on hard optimization problems such as maximum parsimony (MP) and maximum likelihood (ML). Conventional MP heuristics for produc...
Usman Roshan, Bernard M. E. Moret, Tandy Warnow, T...