PeptideMine - A webserver for the design of peptides for protein-peptide binding studies derived from protein-protein interactom

Background: Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target proteins. The identification and validation of these associating domains is crucial to understand signal transduction pathways that modulate different cellular or developmental processes. Bioinformatics strategies to extract and integrate information from diverse sources have been shown to facilitate the experimental design to understand complex biological events. These methods, primarily based on information from high-throughput experiments, have also led to the identification of new connections thus providing hypothetical models for cellular events. Such models, in turn, provide a framework for directing experimental efforts for validating the predicted molecular rationale for complex cellular processes. In this context, it is envisaged that the rational design of peptides for protein-peptide binding studies cou...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Khader Shameer, Lalima L. Madan, Shivamurthy Veeranna, Balasubramanian Gopal, Ramanathan Sowdhamini
• Keywords: BMCBI 2010, Peptide, Protein, Rational Design