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» From genomics to chemical genomics: new developments in KEGG
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BIB
2010
103views more  BIB 2010»
13 years 5 months ago
Challenges of sequencing human genomes
Massively parallel sequencing technologies continue to alter the study of human genetics. As the cost of sequencing declines, next-generation sequencing (NGS) instruments and data...
Daniel C. Koboldt, Li Ding, Elaine R. Mardis, Rich...
BMCBI
2010
133views more  BMCBI 2010»
13 years 7 months ago
Improving de novo sequence assembly using machine learning and comparative genomics for overlap correction
Background: With the rapid expansion of DNA sequencing databases, it is now feasible to identify relevant information from prior sequencing projects and completed genomes and appl...
Lance E. Palmer, Mathäus Dejori, Randall A. B...
BIOINFORMATICS
2010
138views more  BIOINFORMATICS 2010»
13 years 7 months ago
Robust unmixing of tumor states in array comparative genomic hybridization data
Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness, and eventually metastasis. It i...
David Tolliver, Charalampos E. Tsourakakis, Ayshwa...
BMCBI
2005
117views more  BMCBI 2005»
13 years 7 months ago
Differentiation of regions with atypical oligonucleotide composition in bacterial genomes
Background: Complete sequencing of bacterial genomes has become a common technique of present day microbiology. Thereafter, data mining in the complete sequence is an essential st...
Oleg N. Reva, Burkhard Tümmler
BMCBI
2007
107views more  BMCBI 2007»
13 years 7 months ago
A general and efficient method for estimating continuous IBD functions for use in genome scans for QTL
Background: Identity by descent (IBD) matrix estimation is a central component in mapping of Quantitative Trait Loci (QTL) using variance component models. A large number of algor...
Francois Besnier, Örjan Carlborg